Table of Contents

Foreword<br>Introduction<br>1 Scope<br>2 Terms and definitions<br>3 Micronucleus assay methodology used <br>&nbsp;&nbsp;&nbsp;in this standard<br>4 Confidentiality of personal information<br>5 Laboratory safety requirements<br>6 Calibration source(s), calibration curve, and<br>&nbsp;&nbsp;&nbsp;minimum resolvable dose<br>7 Responsibility of the customer<br>8 Responsibility of the CBMN laboratory<br>9 Accidental overexposure involving few individuals<br>10 Population triage<br>11 Quality assurance and quality control<br>Annex A (informative) - Sample data sheet for recording <br>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;micronuclei in binucleated cells<br>Annex B (informative) - Automation of micronuclei scoring<br>Annex C (informative) - Instructions for customer (sample)<br>Annex D (informative) - Sample questionnaire<br>Annex E (informative) - Sample of report for single <br>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;assessment<br>Annex F (informative) - Example group sample report<br>Bibliography

Abstract

Describes the following: a) confidentiality of personal information for the customer and the laboratory; b) laboratory safety requirements; c) radiation sources, dose rates, and ranges used for establishing the calibration reference dose-effect curves allowing the dose estimation from CBMN assay yields and the minimum resolvable dose; d) performance of blood collection, culturing, harvesting, and sample preparation for CBMN assay scoring; e) scoring criteria; f) conversion of micronucleus frequency in binucleated cells into an estimate of absorbed dose; g) reporting of results; h) quality assurance and quality control; and i) informative annexes containing examples of a questionnaire, instructions for customers, a microscope scoring data sheet, a sample report and advice on strengths and limitations of current automated systems for automated micronucleus scoring.

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Published
Document Type	Standard
Status	Current
Publisher	British Standards Institution
Pages
ISBN
Committee	NCE/2